Jobs

Engineer

November 20, 2017 — today
Plateforme informatique, IBENS
Paris, France
supervised by Pierre Vincens

Development and maintenance of applications and tools for internal functionment of IBENS.

  • Recovery of the project for the scolarity management, in Symfony. Deploye application, maintenance and user support (secretary, internal and external student, teaching staff).
  • Writing specifications fon an application to manage IBENS agents assignement, in collaboration with administrators.
  • Analysis and maintenance of an existing project for graphical management of LDAP, in PHP.
  • Legacy script in Perl maintenance (upgrade version) for LDAP CLI. Add associated PerlDoc for each script.

Engineer

2016 — June 2017
LabEx Milieu Intérieur, Institut Pasteur
Paris, France
supervised by Darragh Duffy

Sample data management system conception with data formating before implementation. Shiny (R) scripts development.

  • Sample data formating before uploading on software FreezerPro
  • Shiny (R) development to analyse gene expressions
  • Unity’s Journal Club presentation (in english)
  • Python scripting and file analysis report with Jupyter
  • Work in progress reports towards research unity (in english)

Engineer in bioinformatics

May — December 2015
UMR 946 INSERM - Université Paris Diderot
Paris, France
supervised by Dr Florence Demenais

Common process development (annotations, formating, imputations) for the different research fields of laboratory, prepare genetic data for scientific computing, literature monitoring in science and technology.

  • Interspecies compararison for melanoma using EPOs (human-dag): orthologous genes comparison
  • SNPs annotation along genes
  • Literature monitoring in science and technology for the laboratory
  • Writting documentation for scripts and processes
  • User training for scripts and processes realised

Engineer in bioinformatics

2013 — April 2015
AP-HP Cochin
Paris, France
supervised by Dr Florence Demenais, Dr Marie-Françoise Avril,

Prepare genetic data for scientific computing and common informatics processes.

  • Prepare genotypic data before imputing
  • SNPs annotation along genes
  • Recovery of orthologous genes human-dog from Ensembl
  • Functional annotation (DNAse, transciption binding site…) with UCSC Genome Browser, help interpreting data shown in function of selected database
  • Development of file formating scripts
  • Literature monitoring in science and technology for the laboratory
  • Writting documentation for scripts and processes

Engineer in bioinformatics

2012 — 2013
UMR 946 INSERM-Université Paris Diderot
Paris, France
supervised by Dr Florence Demenais

Identify and use public databases, develop common processes (annotations, formating, imputations) for the different research fields of laboratory, prepare genetic data for scientific computing, literature monitoring in science and technology.

  • Identify public databases
  • Local repository on annotation of genes and SNPs from NCBI
  • SNPs annotation along genes
  • Gene pathway search (KEGG)
  • Support on existing processes
  • Script development in Bash, Perl, VBA (Excel macro)
  • Literature monitoring in science and technology for the laboratory
  • Writting documentation for scripts and processes

Engineer in bioinformatics

February — May 2011
Centre de bioinformatique bordelais
Bordeaux, France
supervised by Macha Nikolski

Web interface development to align short peptids agains protein database for a specific organism. Show peptid sets that match with a same set of proteins and gather proteins information. Allow to determine interactions between genes and protein discovered.

  • Blast of rat’s short peptides over UniProt proteins (localy)
  • Search homologous human genes with OrthoMCL and HomoloGene (NCBI)
  • For each recovered gene, show description in a web interface web : Gene (NCBI)
  • Show peptids aligned with matching proteins using MAFFT
  • Web interface developped in Perl, PHP, JavaScript, HTML, CSS

Trainee, Master 2

March — July 2010
DIMNP (Dynamique des Interactions Membranaires Normales et Pathologiques)
Montpellier, France
supervised by Pr Ovidiu Radulescu

Modelizing the phospholipid metabolism of Plasmodium falciparum

Mathematic approach development to modelise and explain the phospholipid metabolism of Plasmodium falciparum

  • Literature monitoring
  • Modeling with MatLab (SimBiology)

Trainee

June — July 2009
LaBRI (Laboratoire Bordelais de Recherche en Informatique)
Bordeaux, France
supervised by Pascal Desbarats

Website management software conception

Development of a software to help website management with a graphical interface.

  • Python, wxPython, XML, HTML

Training

NGS & Cancer : Analyses ChIP-Seq

April 2015 (3 days)

Cancéropôle Île-de-France

Paris, France

Galaxy, peak-calling, Analyse fonctionnelle et de transcriptome, ChIP-Seq and RNA-Seq crossing data

Education

Master degree in Biologie Santé, Bioinformatique

2008 — 2010

Université de Bordeaux
Bordeaux, France

Functional proteomic and post-genomic, Functional genomic, Division and cell cycle, Computing ressources, Algorithmics, Programming, Database, Data Mining, Imaging

Bachelor degree in Sciences de la Vie et de la Santé, Biologie Cellulaire et Physiopathologie

2004 — 2008

Université Victor Segalen Bordeaux II
Bordeaux, France

Immunology, Physiology, Biochemistry, Chemistry (organic, kinetics, enzymatics), Cellular biology (animal, plants), Microbio- logy, Genetics, Statistics

Publications

Articles

[1]

Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families

Dizier MH and Margaritte-Jeannin P and Pain L and Sarnowski C and Brossard M and Mohamdi H and Lavielle N and Babron MC and Just J and Lathrop M and Laprise C and Bouzigon E and Demenais F and Nadif R

Thorax, 2018 —  10.1136/thoraxjnl-2018-211797 /  30282721
[2]

The COL5A3 and MMP9 genes interact in eczema susceptibility

Margaritte-Jeannin P and Babron MC and Laprise C and Lavielle N and Sarnowski C and Brossard M and Moffat M and Gagné-Ouellet V and Etcheto A and Lathrop M and Just J and Cookson WO and Bouzigon E and Demenais F and Dizier MH

Clin Exp Allergy, 2018 —  10.1111/cea.13064 /  29168291
[3]

A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants

Vaysse A and Fang S and Brossard M and Wei Q and Chen WV and Mohamdi H and Vincent-Fetita L and Margaritte-Jeannin P and Lavielle N and Maubec E and Lathrop M and Avril MF and Amos CI and Lee JE and Demenais F

Int J of Cancer, 2016 —  10.1002/ijc.30245 /  27347659
[4]

Interaction between DNAH9 gene and early smoke exposure on bronchial hyper-responsiveness

Dizier MH and Nadif R and Margaritte-Jeannin P and Barton S and Sarnowski C and Gagné-Ouellet V and Brossard M and Lavielle N and Just J and Lathrop M and Holloway J and Laprise C and Bouzigon E and Demenais F

Eur Respir J, 2016 —  10.1183/13993003.00849-2015 /  26797031
[5]

Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk

Brossard M and Fang S and Vaysse A and Wei Q and Chen W V. and Mohamdi H and Maubec E and Lavielle N and Galan P and Lathrop M and Avril MF and Lee J E. and Amos C I. and Demenais F

Int J of Cancer, 2015 —  10.1002/ijc.29570 /  25892537
[6]

A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults

Bouzigon E and Nadif R and Thompson EE and Concas MP and Kuldanek S and Du G and Brossard M and Lavielle N and Sarnowski C and Vaysse A and Dessen P and van der Valk RJP and Duijts L and Henderson AJ and Jaddoe VWV and de Jongste JC and GABRIEL consortium and EArly Genetics \& Lifecourse Epidemiology (EAGLE) Consortium and Casula S and Biino G and Dizier MH and Pin I and Matran R and Lathrop M and Pirastu M and Demenais F and Ober C

J Allergy Clin Immunol, 2015 —  10.1111/cea.12461 /  25431337
[7]

The nuclear factor I/A NFIA gene is associated with the ashma plus rhinitis phenotype

Dizier MH and Margaritte-Jeanin P and Madore AM and Moffat M and Brossard M and Lavielle N and Sarnowski C and Just J and Cookson W and Lathrop M and Laprise C and Demenais F

J Allergy Clin Immunol, 2014 —  10.1016/j.jaci.2013.12.1074 /  24560411

Exhibitions

[1]

Combined pathway and gene-gene interaction analysis pinpoints biologically relevant genes for a major melanoma prognosis factor

Vaysse A and Fang S and Brossard M and Mohamdi H and Chen WV and Lavielle N and Maubec E and Wei Q and Lathrop M and Avril M-F and Amos CI and Lee JE and Demenais F and MELARISK and MDACC Melanoma Study Groups

American Society of Human Genetics (ASHG), 18-22 Oct. 2014, San Diego, USA
[2]

Interactive effect between DNAH9 gene and early-life tobacco smode exposure in bronchial hyper-responsiveness

Dizier MH and Nadif R and Margaritte-Jeanin P and Barton SJ and Gagné-Ouellet V and Sarnowski C and Brossard M and Lavielle N and Just J and Lathrop M and Holloway JW and Laprise C and Bouzigon E and Demenais F

International Genetic Epidemiology Society (IGES), 28-30 Aug. 2014, Vienna, Austria
[3]

Pathways and gene-gene interactions associated with melanoma risk

Brossard M and Fang S and Vaysse A and Wai Q and Mohamdi H and Chen WV and Lavielle N and Maubec E and Avril M-F and Lathrop M and Lee JE and Amos CI and Demenais F and MDACC Melanoma Study Groups

Meeting of the Melanoma Genetics Consortium (GenoMEL), 7-9 May 2014, Valencia, Spain
[4]

Pathay-based analysis of genome-wide SNP data reveals new candidate genes for susceptibility to melanoma

Brossard M and Vaysse A and Corda E and Jeannin P and Mohamdi H and Chaudru V and Lavielle N and Bressac-de Paillerets B and Avril MF and Lathrop M and Demenais F

Annual Meeting of the American Society of Human Genetics (ASHG), 6-10 Nov. 2012, San Francisco, USA

Associations

Active member of Giroll collective (Gironde logiciel libre, giroll.org)

February 2012 — October 2018

Writter and reviewer on blog bioinfo-fr.net

March 2012 — November 2018

Editorial manager on blog bioinfo-fr.net

April 2015 — Mid-October 2016

Member of RSG France-JeBif (Jeunes Bioinformaticiens de France) association

December 2013 — January 2018

Board member of RSG France-JeBiF (Jeunes Bioinformaticiens de France) association

  • December 2013 — December 2014
  • December 2015 — December 2016

Active member of Parinux

November 2016 — Today

Member of Labsquare

February 2017 — Today

Miscellaneous

Web development:

website management, web server managemont (Nginx), website creation (norore.fr), conception of web application BioInfuse, web application design of Alice project

Graphics:

image modification, photomontage, webdesign (The Gimp, Inkscape), drawing (Krita)

Writtng:

blogging, short stories and novel under pen name (amateur)